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While dietary contributions typically account for 10%20% of total body CoQ10, this proportion increases in individuals with impaired biosynthesis, such as those with genetic mutations in COQ genes ( Lactobacillus , have been identified to synthesize CoQ homologs, which may be absorbed in the colon and subsequently converted into CoQ10 within host tissues ( A study investigated the relationship between CoQ10 and female fertility and indicated that CoQ10 can support healthy oocyte development in women, prevent premature ovarian failure, and increase ovarian sensitivity to estrogen, ultimately leading to improved ovarian function ( in vitro fertilization and embryo transfer (IVF-ET) treatment, resulting in a higher success rate of embryo transfer ( CoQ10 in assisted reproductive technology CoQ10 supplementation has been linked to increased pregnancy rates in both natural conception and ART ( In vitro studies have demonstrated that the addition of 50 M CoQ10 to the culture medium resulted in increased expression of Bcl2 and Sirt1 in cumulus cells, and a positive impact on the reduction of ROS, maturation rate, and first polar body extrusion was enhanced from 48.9% to 75.7% by the addition of CoQ10 to the culture medium (Figure 1)